Why is Ritonavir co formulated with atazanavir?
In addition to providing a pharmacokinetic benefit (as reviewed above and in Table 1), ritonavir boosting of atazanavir improves virologic activity and increases the genetic barrier to resistance.
Which one of the following represents the major statin associated adverse effect?
Myositis and Myalgia The best recognized and most commonly reported AEs of statins are muscle AEs,26, 27 and include muscle pain, fatigue and weakness as well as rhabdomyolysis.
What is a possible side effect of statin intake and one reason some experts express caution about their widespread use?
The FDA’s advice to patients and healthcare professionals include: A warning that statins may cause cognitive impairment. These issues include memory loss, confusion, and forgetfulness. A notice that routine liver enzyme monitoring is no longer necessary.
What type of drug Atazanavir is?
Atazanavir is in a class of medications called protease inhibitors. It works by decreasing the amount of HIV in the blood. Although atazanavir does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer.
What are the two different mechanisms of action for antiretrovirals?
Current ARV mechanisms of action: Block reverse transcriptase to disrupt copying of HIV genetic code (NRTIs; NNRTIs) Block protease enzyme, preventing maturation of new virions (PIs)
Is atazanavir an antiviral drug?
Atazanavir is an antiviral medicine that prevents human immunodeficiency virus (HIV) from multiplying in your body. Atazanavir is used with other medications to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Atazanavir is not a cure for HIV or AIDS.
How is atazanavir synthesized?
The original synthesis of atazanavir. Another efficient and practical synthesis of atazanavir was developed by employing the diastereoselective reduction of ketomethylene aza-dipeptide (34.1.47) as the key and final step.
Is atazanavir a protease inhibitor?
Atazanavir is an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl) hydrazine moiety with activity against both wild type and mutant forms of HIV protease. Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors.
What is the Kröhnke synthesis?
Since its discovery, the Kröhnke synthesis has enjoyed broad applicability to the preparation of di-,tri- and tetrapyridine derivatives, demonstrating a number of advantages over related reactions such as the Hantzsch pyridine synthesis .
Are there any proposed intermediates for the Kröhnke synthesis of tetrapyridine?
The proposed intermediates, 1, 5-dicarbonyl compound 3, have not been isolated. Since its discovery, the Kröhnke synthesis has enjoyed broad applicability to the preparation of di-,tri- and tetrapyridine derivatives, demonstrating a number of advantages over related reactions such as the Hantzsch pyridine synthesis .