What is the role of IL-23?

IL-23 functions in innate and adaptive immunity, and is a key cytokine for promoting inflammatory responses in a variety of target organs. The most important function ascribed to IL-23 is its role in the development and differentiation of effector Th17 cells via activation of STAT3.

How is IL-23 produced?

IL-23 is produced mainly by activated antigen-presenting cells (APC) including dendritic cells (DC). The activation of DC plays a pivotal role in shaping the immune responses.

Is an interleukin a biologic?

To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in disease, investigators have studied how production of the different members of the IL-1 family is controlled, the various biologic activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family, and the complexity …

Is IL 23 a gene?

IL23A (Interleukin 23 Subunit Alpha) is a Protein Coding gene. Diseases associated with IL23A include Autoimmune Cholangitis and Inflammatory Bowel Disease. Among its related pathways are Dendritic Cells Developmental Lineage Pathway and MIF Mediated Glucocorticoid Regulation.

What is the difference between Th1 and Th2 response?

Definition. TH1 immune response refers to the cytokine-mediated immune response generated by TH1 cells against intracellular parasites such as bacteria and virus, while TH2 immune response refers to the cytokine-mediated immune response generated by TH2 cells against large, extracellular parasites such as helminths.

Is Cosentyx an IL-23 inhibitor?

While Cosentyx inhibits IL-17A to treat psoriasis and other autoimmune diseases, mirikizumab blocks a different interleukin, IL-23.

Are interleukins monoclonal antibodies?

Siltuximab (CNTO 328, Sylvant®, Janssen Biotech) is a chimeric monoclonal antibody, an interleukin-6 (IL-6) antagonist, which is indicated for the treatment of patients with multicentric Castleman’s disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.

What’s the difference between interleukins and cytokines?

Interleukins are a group of cytokines that were first seen to be expressed by white blood cells. Cytokines are a broad category of small proteins that are important in cell signaling. They are released by cells and affect the behavior of other cells, and sometimes the releasing cell itself.