What is KRAS wild-type colorectal cancer?
The KRAS gene makes a protein that is involved in cell signaling pathways that control cell growth, cell maturation, and cell death. Mutated (changed) forms of the KRAS gene have been found in some types of cancer, including non-small cell lung cancer, colorectal cancer, and pancreatic cancer.
What is the treatment of stage IV colon cancer wild-type KRAS?
In 2009, the National Comprehensive Cancer Network (NCCN) recommended KRAS testing for patients with stage IV CRC at time of diagnosis, and only patients with tumors of wild-type KRAS gene (KRAS-WT) be treated with anti-EGFR therapy.
What is a wild-type cancer?
A term used to describe a gene when it is found in its natural, non-mutated (unchanged) form. Mutated (changed) forms of certain genes have been found in some types of cancer. Knowing whether a patient’s tumor has a wild-type or mutated gene may help plan cancer treatment.
What does the term wild type mean?
Definition of wild type : a phenotype, genotype, or gene that predominates in a natural population of organisms or strain of organisms in contrast to that of natural or laboratory mutant forms also : an organism or strain displaying the wild type.
Does wild type mean normal?
wild type An individual having the normal phenotype; that is, the phenotype generally found in a natural population of organisms. mutant An individual having a phenotype that differs from the normal phenotype. Wild type is designated with a “+” for any allele.
What are wild type traits?
The wild type (WT) is the phenotype of the typical form of a species as it occurs in nature. Originally, the wild type was conceptualized as a product of the standard “normal” allele at a locus, in contrast to that produced by a non-standard, “mutant” allele.
What is the difference between mutant and wild type?
wild type An individual having the normal phenotype; that is, the phenotype generally found in a natural population of organisms. mutant An individual having a phenotype that differs from the normal phenotype.
What does BRAF wild-type mean?
Wild Type: This term describes genes that have no mutation and are normal. For example, some people have melanoma with mutations in BRAF, while others have so-called wild type BRAF melanoma, meaning there’s no known mutation present.
How wild type is determined?
The designation of wild type is based upon a quantitative (numerical) representation or estimation of the norm (normal) or standard in a population. For example, one of the first descriptions of a wild-type gene was made with reference to the Drosophila fruit fly.
How do you treat KRAS mutation?
Standard first-line therapy for a patient with KRAS positive lung cancer may be surgery, radiation, chemotherapy, immunotherapy or a combination based on the stage of their cancer. There is now a targeted therapy pill (also called a KRAS inhibitor) for patients with KRAS G12C.
Is KRAS wild type positive or negative?
In July 2012, the indication for cetuximab was updated to specify treatment of KRAS mutation-negative (wild-type), EGFR-expressing, metastatic colorectal cancer as determine by FDA-approved tests (eg, therascreen KRAS RGQ PCR kit).