What is high grade DCIS with comedo necrosis?
High-grade DCIS has a higher risk of coming back than low- or moderate-grade DCIS. High-grade DCIS may be described as comedo or comedo necrosis, which means there are areas of dead cancer cells inside the DCIS.
What is comedo-type necrosis?
Answer: The term ‘necrosis’ refers to cells that are dying. When cells die, they often attract other chemicals in the body, and form something called ‘comedo necrosis,’ which is basically the residual, leftover dead cells.
What does DCIS nuclear grade 3 mean?
DCIS that is high grade, is nuclear grade 3, or has a high mitotic rate is more likely to come back (recur) after it is removed with surgery. DCIS that is low grade, is nuclear grade 1, or has a low mitotic rate is less likely to come back after surgery.
What is comedo-type DCIS?
Comedo-DCIS is a histologic subtype of preinvasive breast neoplasia that is characterized by prominent apoptotic cell death and has greater malignant potential than other DCIS subtypes. We investigated the mechanisms of apoptosis in comedo-DCIS and its role in conversion of comedo-DCIS to invasive cancer.
What is the treatment for DCIS stage 3?
Radiation therapy Treatment of DCIS has a high likelihood of success, in most instances removing the tumor and preventing any recurrence. In most people, treatment options for DCIS include: Breast-conserving surgery (lumpectomy) and radiation therapy. Breast-removing surgery (mastectomy)
What does comedo type mean?
A comedo-type ductal carcinoma in situ, also known as comedocarcinoma in situ is the high grade subtype of ductal carcinoma in situ (DCIS). It completely fills and dilates the ducts and lobules in TDLU with plugs of high grade tumor cells with central necrosis “comedonecrosis”.
What is the meaning of comedo?
Definition of comedo : a small bump or blemish on the skin (as of the face or back) usually containing a plug of sebum in a skin pore: such as. a or open comedo : blackhead sense 1. b or closed comedo : whitehead.
What is grade 3 invasive ductal carcinoma prognosis?
The relative 5-year survival rate for stage 3 breast cancer is 86 percent, according to the American Cancer Society . This means that out of 100 people with stage 3 breast cancer, 86 will survive for 5 years.
Is Comedo carcinoma invasive?
Comedocarcinomas are known as the most aggressive form of intraductal carcinomas, although they are considered to be an early stage of breast cancer and are classified as noninvasive.
How are comedones formed?
Comedones form when excess oil and dead skin cells block the oil-producing glands in the skin. This causes the affected pores to bulge outward, creating the bumps. Several factors can contribute to the development of comedonal acne.
Is high-grade DCIS serious?
Overall, pure DCIS has an excellent prognosis; however, high-grade DCIS is an aggressive subtype with significantly greater morbidity and risk of mortality with recurrent invasive disease.
What is comedo in medical term?
Can comedones spread?
If a comedone rests on your face, there are chances that its bacteria that can spread to other areas of your face.