What is a cyclodextrin and what is it used for?
Cyclodextrins are a family of cyclic oligosaccharides with widespread usage in medicine, industry and basic sciences owing to their ability to solubilize and stabilize guest compounds. In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents.
Why is cyclodextrin important?
The mainly uses of cyclodextrins are complexing agents to increase aqueous solubility of poorly soluble drugs, as well as, increase their bioavailability and stability. The other application of CDs is to crosslink for forming polymers which used in drug delivery.
What drugs use cyclodextrin?
Examples of the use of cyclodextrins in medicines on the European market are β-CD in cetirizine tablets and cisapride suppositories, γ-CD in minoxidil solution, and examples of the use of β-cyclodextrin derivatives are SBE-β-CD in the intravenous antimycotic voriconazole, HP-β-CD in the antifungal itraconazole.
What foods contain cyclodextrin?
Alpha-cyclodextrins are annular, purely plant-based molecules which are obtained from renewable raw materials, such as potatoes and corn. They can be added to beverages, dairy products, muesli bars and breakfast cereals, for example, to provide dietary fiber.
What is cyclodextrin inclusion complex?
Cyclodextrins (CDs) are cyclic oligosaccharides which provide an interesting organic host system, since they have a hydrophobic inner cavity available to form non-covalent host-guest inclusion complexes with a wide variety of organic molecules of appropriate shape and size [11].
Is Cyclodextrin edible?
This is very valuable especially for the food industry, as only alpha- and gamma-cyclodextrin can be consumed without a daily intake limit.
Are cyclodextrins toxic?
When administered orally, cyclodextrins are not absorbed from gastrointestinal tract and thus are practically nontoxic. This is due to their bulky and hydrophilic nature.
How do you take complex cyclodextrin?
The guest is dissolved in organic solvents (such as chloroform, benzene and diethyl ether, etc), and appropriate amount of cyclodextrin dissolved in water is added with agitation. The solution is cooled and complex crystals occur. The crystals are washed with organic solvent and then dried at 50°C [11,13].
What is the meaning of inclusion complex?
Definition: A complex in which one component (the host) forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species (the guest) are located.
Does cyclodextrin clear arteries?
An international team has now found that cyclodextrin dissolves cholesterol crystals and reduces atherosclerotic plaques. This is a promising therapeutic approach for treating atherosclerosis.
What are inclusion complexes with examples?
How do you make cyclodextrin complex?
What dissolves plaque buildup in arteries?
There are no quick fixes for melting away plaque, but people can make key lifestyle changes to stop more of it accumulating and to improve their heart health. In serious cases, medical procedures or surgery can help to remove blockages from within the arteries.
Can monotosyl-β-cyclodextrin (mono-TS-βCD) be substituted for substituted βCD?
Applicability proposed for coupling of mono-Ts-βCD to nucleophilic molecules. 6- O -Monotosyl-β-cyclodextrin (mono-Ts-βCD) is one of the most important intermediates in the production of substituted βCD.
What is the reaction of cyclodextrin with p-toluenesulfonyl chloride?
Here, the reaction of cyclodextrin with p -toluenesulfonyl chloride in aqueous environment is described to obtain a highly pure mono-Ts-βCD, for which a single-step purification with a cation exchange resin was applied.
What is the best strategy for nucleophilic substitution of tosylated cyclodextrins?
This synthesis procedure with a direct collection of side-products may be a general strategy applicable for nucleophilic substitution of tosylated cyclodextrins.
What is the molar purity of Mono-TS-βCD?
As characterized by FTIR, mass spectrometry, elemental analysis, and NMR, mono-Ts-βCD was obtained with a molar purity of >98 mol %.