What are statin drugs used to treat?

Statins are a group of medicines that can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol is often referred to as “bad cholesterol”, and statins reduce the production of it inside the liver.

How statins work?

Statins work by reducing the amount of cholesterol made by the liver and helping the liver remove cholesterol that is already in the blood. Statins may also reduce inflammation in the artery walls. This can lead to blockages that damage organs such as the heart and brain.

Is simvastatin polar or nonpolar?

Hydrophilicity (pravastatin and rosuvastatin) originates from the common active site plus other polar substituents, whereas lipophilicity (atorvastatin, lovastatin, fluvastatin, pitavastatin, simvastatin, and cerivastatin) arises because of the addition of nonpolar substituents.

What is mode of action of rosuvastatin?

Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

What organ do statins affect?

Statins do this by blocking your body’s production of an enzyme called HMG-CoA reductase. This is the enzyme your liver needs to make cholesterol. Blocking this enzyme causes your liver to make less cholesterol, which makes it easier for your body to remove cholesterol that’s already in your blood.

What are the dangers of statins?

Side effects can vary between different statins, but common side effects include:

• headache.
• dizziness.
• feeling sick.
• feeling unusually tired or physically weak.
• digestive system problems, such as constipation, diarrhoea, indigestion or farting.
• muscle pain.
• sleep problems.
• low blood platelet count.

Do statins make arthritis worse?

Use of statins is associated with an increased risk of rheumatoid arthritis.

Can rosuvastatin cause heart problems?

This baffled Gullicksen, and he began researching Crestor online. He found the drug was linked to a laundry list of side effects, including heart problems, dark urine, kidney failure and muscle pains.