What are the main treatment strategies used in the management of gout?

In general, anti-inflammatory therapy should be begun immediately, preferably within 12 to 24 hours of onset of an acute gout flare (B). First-line treatment options are nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, and colchicine (5) (A). Treatment usually relieves symptoms after 24 hours (19).

What is uricosuric therapy?

Uricosuric Therapy of Hyperuricemia in Gout Uricosuric drugs were the first agents used to control hyperuricemia in patients with gout. 1. Any drug that increases renal excretion of uric acid, independently of the mechanism through which it exerts its effect, may be considered a uricosuric drug.

What is refractory gout?

Refractory gout (also known as treatment failure gout) is a clinical condition that is characterized by serum uric acid levels that do not fall below 6 mg/dL, and ongoing symptoms of recurrent flares, chronic inflammatory arthritis, and increased tophi.1.

What is first line therapy for gout?

First-line therapy for acute gout is nonsteroidal anti-inflammatory drugs or corticosteroids, depending on comorbidities; colchicine is second-line therapy. After the first gout attack, modifiable risk factors (e.g., high-purine diet, alcohol use, obesity, diuretic therapy) should be addressed.

Which of the following is first line therapy recommended to consider in gout?

Allopurinol is strongly recommended as a first-line urate-lowering medication over all others for all patients. Allopurinol or febuxostat is strongly recommended over probenecid as a first-line treatment for patients with moderate-to-severe chronic kidney disease.

What is first line treatment for gout?

Which drug is a uricosuric agent?

Uricosuric agents like benzbromarone and probenecid are very useful to treat hyperuricemia as well as allopurinol (xanthine oxidase inhibitor). Uricosuric agents act the urate lowering effect through blocking the URAT1, an urate transporter, in brush border of renal proximal tubular cells.

Which is better for gout colchicine or prednisone?

Janssens and colleagues suggest that corticosteroids might be a safer approach than colchicine or non-steroidal anti-inflammatory drugs (NSAIDs) and conclude that their results provide a strong argument to consider prednisolone as a first treatment option in patients with gout.

Which of the following is used in chronic gout?

The correct answer is B. Allopurinol.

Is there an alternative to colchicine?

ColciGel® is a first line agent in the treatment of acute gout flares and an alternative to oral colchicine in those patients who experience either adverse drug effects (ADRs) or who do not achieve suitable symptom relief.

Which uricosuric drug is not used acute gout?

Uricosuric agents lower uric acid levels by inhibiting renal tubular reabsorption of uric acid, thereby increasing net renal excretion of uric acid. These agents increase the risk of renal stones, with about a 9-10% risk for probenecid. They should not be started during an attack of acute gouty arthritis.