Who discovered human parvovirus?
The first human parvovirus that was discovered was the B19 parvovirus. This virus was discovered by a virologist named Yvonne Cossart in London in the 1970¹s while investigating laboratory assays for hepatitis B.
How do Parvoviruses replicate?
Parvoviruses replicate their genome via rolling hairpin replication, a unidirectional, strand displacement form of DNA replication that is initiated by NS1. Replication begins once NS1 binds to and makes a nick in a replication origin site in the duplex DNA molecule at the end of one hairpin.
Is parvovirus RNA or DNA?
The parvoviruses (parvo meaning small) are a group of very small DNA viruses that are ubiquitous and infect many species of animals.
How is Papovaviridae acquired?
Transmission of human papillomavirus occurs by direct contact with another infected person, by autoinoculation (e.g., common warts spread by scratching), or by indirect contact (e.g., plantar warts acquired in showers). Genital warts are sexually transmitted.
Why is parvovirus called B19?
The virus was discovered by chance in 1975 by Australian virologist Yvonne Cossart. It gained the B19 name because it was discovered in well B19 of a large series of microtiter plates.
Where did parvo originate from?
Abstract. Canine parvovirus (CPV-2), first recognized in 1978 as a new pathogen of dogs, was probably derived from a very closely related virus in cats, feline panleukopaenia virus (FPLV) or a closely related carnivore parvovirus (FPLV-like virus).
Whats is a virion?
Definition of virion : a complete virus particle that consists of an RNA or DNA core with a protein coat sometimes with external envelopes and that is the extracellular infectious form of a virus.
In which cells of the body can human parvoviruses multiply?
In patients, productive B19V infection is highly restricted to erythroid progenitor cells of the bone marrow (99). B19V was first demonstrated to infect cultured erythroid progenitor cells isolated from human bone marrow cells (100).
What kind of virus is parvovirus?
The virus that causes the disease known as “parvo”, canine parvovirus type 2 (CPV), first emerged among dogs in Europe around 1976. By 1978 the virus had spread unchecked, causing a worldwide epidemic of myocarditis and inflammation in the intestines (gastroenteritis).
What is the largest RNA virus?
Coronaviruses are single-stranded, positive-sense RNA viruses and have the largest genomes known [around 30 kilobases (kb); refs. 1 and 2] among RNA viruses.