What is mosquito cell line?
Cell lines derived from appropriate mosquito hosts provide a relatively simple tool for investigating the interaction between the host and viruses transmitted by mosquitoes.
What is special about Vero cells?
In addition, Vero cells have been licensed in the United States for production of both live (rotavirus, smallpox) and inactivated (poliovirus) viral vaccines, and throughout the world Vero cells have been used for the production of a number of other viruses, including Rabies virus, Reovirus and Japanese encephalitis …
What type of cells are Vero cells?
Vero cells are a lineage of cells used in cell cultures. The ‘Vero’ lineage was isolated from kidney epithelial cells extracted from an African green monkey (Chlorocebus sp.; formerly called Cercopithecus aethiops, this group of monkeys has been split into several different species).
Why are Vero cells used to grow viruses?
Firstly, the cell bank is easy to establish and preserve, at the same time it can be continuously passaged with a fast growth rate. Secondly, Vero cells have stable genetic traits and a low probability of malignancy. Thirdly, Vero cells are sensitive to a variety of viruses and have high virus titers.
How many strains of dengue virus are there?
There are four DENV serotypes (DENV-1, − 2, − 3, and − 4) circulating and transmitted by the Aedes mosquitoes vector [8, 12]. Dengue clinical manifestations vary; they can be in the form of acute febrile illness, classical dengue fever (DF) or dengue hemorrhagic fever (DHF).
Which dengue serotype is most severe?
Severe dengue affected 6.6 % of all cases, of which 32.3 % of the cases caused by DENV-2, 6.4 % of those caused by DENV-4, 4.5 % of those caused by DENV-1, and none of those caused by DENV-3. Severe dengue was found to be seven times more frequent among cases of DENV-2 than among those of the other serotypes.
Which vaccines have Vero cells?
The Vero cell line is the most widely accepted CCL by regulatory authorities and has been used for over 30 years for the production of polio and rabies virus vaccines.
What are the four dengue strains?
There are four serotypes of dengue viruses, designated as DENV-1, DENV-2, DENV-3, and DENV-4; all are transmitted from human to human through the bite of certain species of Aedes mosquitoes, primarily Ae. aegypti and Ae. albopictus.
What are the strains of dengue?
Dengue is caused by a virus of the Flaviviridae family and there are four distinct, but closely related, serotypes of the virus that cause dengue (DENV-1, DENV-2, DENV-3 and DENV-4). Recovery from infection is believed to provide lifelong immunity against that serotype.
Which vaccine is best for Covid?
A Pfizer-BioNTech or Moderna mRNA booster is preferred in most situations. (Only Pfizer boosters are authorized for children and teenagers.) Adults ages 50 and older should get a second booster four months after the first.