What is aripiprazole depot used for?

Aripiprazole extended-release injection (Abilify Maintena) is also used for the ongoing treatment of people with bipolar I disorder (manic-depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods).

How do you administer aripiprazole depot?

Aripiprazole LAI should be administered once monthly (not 4 weekly) by the intramuscular route into the gluteal or deltoid muscle. It should not be administered intravenously or subcutaneously. The recommended dose is 400mg once per calendar month if there are no tolerability, metabolism or interaction issues.

What is the difference between ABILIFY and Abilify Maintena?

They both contain the active ingredient aripiprazole, an atypical antipsychotic, and are approved for the treatment of schizophrenia and bipolar disorder. Abilify is approved for other uses, too. Abilify comes as an oral medication taken daily, while Abilify Maintena is a long-acting injection given every 4 weeks.

Can Abilify Maintena be given in the deltoid?

Abilify Maintena is injected into the deltoid (upper arm) muscle or gluteal (buttock) muscle. It comes in a single-use prefilled syringe or vial for reconstitution. You may feel a little pain in your arm or buttock during your injection. It is only given into a muscle.

How quickly does aripiprazole depot work?

For the first 2 weeks of the initial depot injection, oral aripiprazole should be continued to allow adequate time for the intramuscular medication to reach adequate plasma concentrations, which we know can take approximately 6–12 days.

What is the difference between Aristada and Abilify Maintena?

Although they both contain aripiprazole, sometimes people will need to switch from Abilify Maintena to Aristada because of: Insurance plan coverage. Needing a long acting injectable medication. Abilify Maintena is administered monthly, but Aristada can be administered monthly, every six weeks or every two months.

What is the difference between Aristada and Maintena?

What is Abilify Maintena approved for?

FDA Approves Once-Monthly ABILIFY MAINTENA™ (Aripiprazole) For Extended-Release Injectable Suspension for the Treatment of Schizophrenia. Approval provides patients with schizophrenia the ability to access the efficacy and safety profile of oral aripiprazole in a once-monthly formulation.

What is the best time to take aripiprazole?

You can take aripiprazole either before or after meals. Try to get into the habit of taking your doses at the same time of day each day, as this will help you to remember to take it. If you do forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose.

What is the difference between Aristada and Aristada initio?

ARISTADA INITIO is intended for single administration in contrast to ARISTADA which is administered monthly, every 6 weeks, or every 8 weeks. Do not substitute ARISTADA INITIO for ARISTADA because of differing pharmacokinetic profiles.

How often is Aristada injection given?

The recommended ARISTADA dosing interval is monthly for the 441 mg, 662 mg and 882 mg doses, every 6 weeks for the 882 mg dose, or every 2 months for the 1064 mg dose and should be maintained. In the event of early dosing, an ARISTADA injection should not be given earlier than 14 days after the previous injection.

Is Aristada and Abilify the same?

Abilify Maintena contains the active ingredient aripiprazole. These two active ingredients aren’t exactly the same. After you take Aristada, your body turns the prodrug* aripiprazole lauroxil into aripiprazole. Both Aristada and Abilify Maintena belong to a drug class called antipsychotic drugs.

Are Aristada and Abilify the same thing?

Aristada and Aristada Initio are both aripiprazole lauroxil injections, the long-acting version of Abilify (aripiprazole) used to treat schizophrenia. Aristada Initio is used as a loading dose to jumpstart your treatment on Aristada.

Is ABILIFY MAINTENA approved for bipolar?

ABILIFY MAINTENA is the first and only FDA-approved once-monthly* maintenance treatment for bipolar I in adults. It is an injection that is prescribed by your healthcare provider. Some adults with bipolar I may take a pill to manage their condition. For some, that may mean taking a pill every day.

What is the difference between ARISTADA and ABILIFY MAINTENA?

What is aripiprazole used for in bipolar disorder?

Aripiprazole is indicated for the treatment of moderate to severe manic episodes in Bipolar I Disorder and for the prevention of a new manic episode in adults who experienced predominantly manic episodes and whose manic episodes responded to aripiprazole treatment (see section 5.1).

How is aripiprazole Lai prescribed in the US?

1.4 All patients to be prescribed aripiprazole LAI must be recorded on the Trust patient database via submission of a patient notification form. (See appendix). 1.5 Aripiprazole LAI is intended for once-monthly injection (ie. once per calendar month, rather than 4-weekly), by intramuscular route into the glutealmuscle.

What is the ATC code for aripiprazole?

Pharmacotherapeutic group: Psycholeptics, other antipsychotics, ATC code: N05AX12 It has been proposed that aripiprazole’s efficacy in schizophrenia and Bipolar I Disorder is mediated through a combination of partial agonism at dopamine D 2 and serotonin 5-HT 1A receptors and antagonism of serotonin 5-HT 2A receptors.

Who prepared the guidelines for aripiprazole long-acting injections?

Guidelines prepared by: Jed Hewitt Chief Pharmacist – Governance & Professional Practice. Originally approved by the Drugs & Therapeutics Group: April 2014 (Minor amendments made in August 2014) Date of next full review: April 2016 Appendix (v2) Aripiprazole Long-Acting Injection (Abilify Maintena Patient Notification Form