What does IgG subclass 2 mean?

IgG2 subclass deficiency is the most common subclass deficiency associated with recurrent infection. It may be accompanied by IgG4 deficiency, IgA deficiency, or both. Pure IgG subclass deficiency is rare in association with chronic lymphocytic leukemia.

What does it mean if IgG Subclass 2 is high?

elevated IgG levels can be seen in chronic active infection or inflammation, or in association with plasma cell disorders.

What are IgG subclasses?

IgG is composed of four subclasses: IgG1, IgG2, IgG3, and IgG4 [1-9]. The structure, genetics, and function of the IgG subclasses are reviewed in this section. Detailed discussions of these topics as they apply to immunoglobulins in general are presented separately.

What does IgG subclass test for?

The measurement is useful for diagnosis of IgG subclass deficiency, to aid the diagnosis of specific antibody deficiency, as a supporting test for the diagnosis of common variable immunodeficiency, as well as for risk stratification of patients with low IgA.

What are the symptoms of hypogammaglobulinemia?

Which symptoms you or your child has will depend on what infections you get, but they can include:

• coughing.
• sore throat.
• fever.
• ear pain.
• congestion.
• sinus pain.
• diarrhea.
• nausea and vomiting.

What are the symptoms of Hypogammaglobulinemia?

When do you treat hypogammaglobulinemia?

Treatment options People who get severe or frequent bacterial infections may need to take antibiotics for several months at a time to prevent them. If your hypogammaglobulinemia is severe, you may get immune globulin replacement therapy to replace what your body isn’t making. You get this treatment through an IV.

Is hypogammaglobulinemia an autoimmune disorder?

Many autoimmune diseases have been described in the course of hypogammaglobulinemia, such as cytopenias, inflammatory bowel disease, seronegative arthritis, Sjögren’s syndrome, uveitis, vasculitis, and vitiligo (22,23). Agondi et al.

What happens if immunoglobulin G is high?

High levels of IgG can mean you have an autoimmune disorder. An autoimmune disorder causes your immune system to attack healthy cells, tissues, and/or organs by mistake. These disorders can cause serious health problems.