What does ERK protein mean?
Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family that is involved in both vasoconstriction and vascular smooth muscle cell growth and this, therefore, makes it attractive therapeutic target for treatment of hypertension.
Is ERK1 2 a protein?
Extracellular signal-regulated protein kinase (ERK)1/2 is a mitogen-activated protein kinase (MAPK) family protein with typical cascade signaling characteristics and serves an important role in signal transduction pathways and the function of transcription factors, including activator protein-1, proto-oncogene c-Fos (c …
What does ERK1 2 stand for?
extracellular signal-regulated kinase 1/2
Abstract. The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes, including mainly proliferation, differentiation, and survival, but apoptosis and stress response as well.
What is ERK gene?
MyGenes for gene MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
What is total ERK?
The Total-ERK assay quantifies the expression level of ERK in a cell lysate. Contrary to Western Blot, the assay is entirely plate-based and does not require gels, electrophoresis or transfer. The Total-ERK assay uses two labeled antibodies: one coupled to a donor fluorophore, the other to an acceptor.
What is ERK receptor?
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
What happens when ERK is activated?
The phosphorylation of ERK results in an activation of its kinase activity and leads to phosphorylation of its many downstream targets involved in regulation of cell proliferation.
What does MEK ERK mean?
The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to transcription factors, which regulate gene expression.
What type of kinase is ERK?
serine/threonine protein kinase
ERK, a type of serine/threonine protein kinase, is a signal transduction protein that transmits mitogen signals (32). ERK is generally located in the cytoplasm; upon activation, ERK enters the nucleus and regulates transcription factor activity and gene expression (33).
Where is the RAF protein located?
Abstract. Protein kinase RAF is strategically located in the “Ras – MAP-kinase signal transduction pathway”, a principle system which transmits signals from growth factor receptors to the nucleus, resulting in cell proliferation.
What is the function of RAF protein?
Function of Raf family kinases has been shown to play a role during organism development, cell cycle regulation, cell proliferation and differentiation, cell survival and apoptosis and many other cellular and physiological processes.
How is RAF protein activated?
RAF activation is initiated by RAS-GTP association with the RAS binding domain (RBD) situated within the N-terminal regulatory region of the kinase.