What does angiopoietin 2 do?

Angiopoietin-2 is produced and stored in Weibel-Palade bodies in endothelial cells and acts as a TEK tyrosine kinase antagonist. As a result, the promotion of endothelial activation, destabilization, and inflammation are promoted. Its role during angiogenesis depends on the presence of Vegf-a.

What does Tie2 stand for?

The endothelial-specific receptor, tyrosine kinase with immunoglobulin-like loops and epidermal growth factor homology domains-2 (Tie2) is a member of the tyrosine kinase family and is ubiquitous in normal tissues; however, little is known about the mechanisms and roles of Tie2 in oral squamous cell carcinomas (OSCCs).

Is angiopoietin a protein?

Angiopoietin-like proteins (ANGPTLs) are a family of proteins structurally similar to the angiopoietins. To date, eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. Emerging evidence implies a key role for ANGPTLs in the regulation of a plethora of physiological and pathophysiological processes.

Is angiopoietin 1 a growth factor?

Vascular endothelial growth factor (VEGF) and Angiopoietins are families of vascular-specific growth factors that regulate blood vessel growth, maturation and function.

How is VEGF activated?

VEGF ligands activate angiogenic programs through binding of several receptors. VEGFR-1 (Flt-1) binds VEGF, VEGF-B, and PlGF -1,2 and promotes recruitment of endothelial progenitors and monocyte migration. VEGFR-2 (Flk-1/KDR) is expressed on nearly all endothelial cells and binds VEGF, VEGF-C, VEGF-D, and VEGF-E.

Where is VEGF made?

VEGF is produced by hypertrophic chondrocytes in the growth plate where it co-ordinates extracellular matrix (ECM) remodelling, angiogenesis, and bone formation. VEGF is expressed in the synovial fluid of patients with rheumatoid arthritis.

Who discovered VEGF?

Napoleone Ferrara and his colleagues at Genentech were the first to isolate and clone vascular endothelial growth factor (VEGF) in 1989. His laboratory has investigated many aspects of VEGF biochemistry and molecular biology.